周延廷

发布时间：2018-03-19 14:07:04 点击次数：2462

周延廷(英文名Kevin Zhou)，1984年毕业于南方医科大学，获医学学士学位。1989年到美国德州大学西南医学中心做博士后，1992年升为讲师，1996年升为教授。2002在德州大学西南医学中心完成内科住院医生训练，2004年在克里夫兰Case大学医院完成心血管病学专科训练，并取得美国医学专业委员会（ABIM）认证的内科和心血管系统疾病专科医生资格。从2004年起成为华盛顿州的执照医生，从2005年起担任FACC会员。现任CHI Fraciscan Health King County 心内科主任(包括3家医院4个门诊)。鉴于周教授在心脏病学领域的卓越成就，现特聘为同济大学附属东方医院心脏内科顾问委员会委员和同济大学医学与生命科学部咨询委员会委员。

专业建树：在美国接受系统严格的心血管专科医生训练，长期从事心脏内科临床和管理工作，具有丰富的临床经验和深厚的学术造诣。熟练掌握心内科常见病、多发病及急危重症的诊治，尤其擅长心脏起搏器植入术、心导管术和心脏影像学诊断。

科研业绩：共发表SCI论文25篇，参编英文专著1部，获得专利4项。

Publications

1.Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acidspillover. Diabetes. 2001 Feb;50 Suppl 1:S118-21.

2.Wang ZW, Pan WT, Lee Y, Kakuma T, Zhou YT, Unger RH. The role of leptin resistance in the lipid abnormalities of aging. FASEB J. 2001 Jan;15(1):108-114.

3.Kakuma T, Wang ZW, Pan W, Unger RH, Zhou YT. Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 exPssion.

Endocrinology. 2000 Dec;141(12):4576-82.

4.Lee Y, Wang MY, Kakuma T, Wang ZW, Babcock E, McCorkle K, Higa M, Zhou YT, Unger RH. Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem. 2001 Feb 23;276(8):5629-35.

5.Wang Z, Zhou YT, Kakuma T, Lee Y, Kalra SP, Kalra PS, Pan W, Unger RH. Leptin resistance of adipocytes in obesity: role of supPssors of cytokine signaling.

Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.

6.Chen S, Wang Z, Zhou YT, Grayburn PA. Optimization of the size distribution and myocardial contrast effect of perfluorocarbon-filled albumin microbubbles by lyophilization under continuous negativePssure. J Am Soc Echocardiogr. 2000 Aug;13(8):748-53.

7.Shohet RV, Chen S, Zhou YT, Wang Z, Meidell RS, Unger RH, Grayburn PA.

Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation. 2000 Jun 6;101(22):2554-6.

8.Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, Orci L, Unger RH. Lipotoxic heart disease in obese rats: implications for human obesity.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1784-9.

9.Higa M, Zhou YT, Ravazzola M, Baetens D, Orci L, Unger RH. TroglitazonePvents mitochondrial alterations, beta cell destruction, and diabetes in obesePdiabetic rats. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11513-8.

10.Wang ZW, Zhou YT, Kakuma T, Lee Y, Higa M, Kalra SP, Dube MG, Kalra PS, Unger RH. Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10373-8.

11.Wang ZW, Zhou YT, Lee Y, Higa M, Kalra SP, Unger RH. Hyperleptinemia depletes fat from denervated fat tissue. Biochem Biophys Res Commun. 1999 Jul 14;260(3):653-7.

12.Zhou YT, Wang ZW, Higa M, Newgard CB, Unger RH. Reversing adipocyte differentiation: implications for treatment of obesity. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2391-5.

13.Unger RH, Zhou YT, Orci L. Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2327-32.

14.Zhou YT, Shimabukuro M, Lee Y, Koyama K, Higa M, Ferguson T, Unger RH.

Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets ofPdiabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes.

Diabetes. 1998 Dec;47(12):1904-8.

15.Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH.

Lipoapoptosis in beta-cells of obesePdiabetic fa/fa rats. Role of serine palmitoyltransferase overexPssion.

J Biol Chem. 1998 Dec 4;273(49):32487-90.

16.Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH.

Protection against lipoapoptosis of beta cells through leptin-dependent

maintenance of Bcl-2 exPssion.

Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9558-61.

17.Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, Newgard CB, Unger RH. Role of peroxisome proliferator-activated receptor alpha in disease of

pancreatic beta cells. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8898-903.

18.Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2498-502.

19.Shimabukuro M, Zhou YT, Lee Y, Unger RH. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem. 1998 Feb 6;273(6):3547-50.

20.Zhou YT, Shimabukuro M, Lee Y, Koyama K, Trieu F, Unger RH. Leptin normalizes the impaired response of proinsulin mRNA to long chain fatty acids in heterozygous Zucker diabetic fatty rats. J Biol Chem. 1997 Oct 10;272(41):25648-51.

21.Shimabukuro M, Zhou YT, Lee Y, Unger RH. Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats. Biochem Biophys Res Commun. 1997 Aug 18;237(2):359-61.

22.Zhou YT, Shimabukuro M, Koyama K, Lee Y, Wang MY, Trieu F, Newgard CB, Unger RH. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6386-90.

23.Lee Y, Hirose H, Zhou YT, Esser V, McGarry JD, Unger RH. Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.

Diabetes. 1997 Mar;46(3):408-13.

24.Chen G, Koyama K, Yuan X, Lee Y, Zhou YT, O'Doherty R, Newgard CB, Unger RH. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14795-9.

25.Wang MY, Zhou YT, Newgard CB, Unger RH. A novel leptin receptor isoform in rat. FEBS Lett. 1996 Aug 26;392(2):87-90.

Book Chapter:  Diabetes Mellitus: A Fundamental and Clinical Text, Second Edition. Chapter 12, pp132-141. Published by Lippincott Williams & Wilkins (Baltimore, MD), 1999.