朱伟东
发布时间:2016-06-22 11:59:47
点击次数:2551
朱伟东,博士,教授、博士生导师,同济大学心律失常教育部重点实验室同济大学、同济大学东方转化医学研究中心(东方医院)PI。1990年毕业于上海第二军医大学,获医学学士学位。1996年在日本东京大学大学从事心血管病研究。2000年获得日本东京大学心血管博士学位。2001至2002年在美国哈佛大学从事儿童心血管方面研究(博士后)。2009年回国受聘为同济大学医学院特聘教授,同济大学心律失常教育部重点实验室副主任、同济大学转化医学研究中心(东方医院)PI。
自1996年开始主要从事心脏疾病的发生发展以及如何阻止其发生发展的分子机制研究,包括心肌肥厚、缺血性心脏病和心衰的发生和发展,以及为阻止这些疾病的治疗方法提供新的理论基础。2009年底回国后率领团队继续深入该领域的研究,发现了新的阻止心脏疾病发生的分子机制,这些研究为心脏疾病的治疗提供了新靶点。发表 SCI 论文 20 余篇,其中数篇见刊于 Nature,Cell,Nature Medicine 等顶级杂志,被引用近2000次。
一、 代表性论文
Wo D#, Peng J#, Ren DN#, Qiu L#, Chen J, Zhu Y, Yan Y, Yan H, Wu J, Ma E, Zhong TP, Chen Y, Liu Z, Liu S, Ao L, Liu Z, Jiang C, Peng J, Zou Y*, Qian Q*,
Zhu W*. Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkkl in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin. Circulation 2016; 134:1991-2007
He Q, Yan H, Wo D, Liu J, Liu P, Zhang J, Li L, Zhou B, Ge J, Li H, Liu S*, Zhu W*.Wnt3a suppresses Wnt/β-catenin signaling and cancer cell proliferation following serum deprivation. Exp Cell Res, 2016; 341:32-41
Ren DN#, Chen J#, Li Z#, Yan H, Yin Y, Wo D, Zhang J, Ao L, Chen B, Ito TK, Chen Y, Liu Z, Li Y, Yang J, Lu X, Peng Y, Pan L, Zhao Y, Liu S, Zhu W. LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis. Nat Commun, 2015; 6:6906
Chen J#, Yan H#, Ren DN#, Yin Y#, Li Z, He Q, Wo D, Ho MS, Chen Y, Liu Z, Yang J, Liu S, Zhu W. LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathwayactivation. Cell Signal, 2014; 26:1068-1074
Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M, Komuro I. IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature 2008;454:345-9
Harada M, Qin Y, Takano H, Minamino T, Zou Y, Toko H, Ohtsuka M, Matsuura K, Sano M, Nishi J, Iwanaga K, Akazawa H, Kunieda T, Zhu W, Hasegawa H, Kunisada K, Nagai T, Nakaya H, Yamauchi-Takihara K, Komuro I. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 2005;11:305-11
Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I. Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease. J Biol Chem 2000;275(45):35291-6
Zhu W, Zou Y, Shiojima I, Kudoh S, Aikawa R, Hayashi D, Mizukami M, Toko H, Shibasaki F, Yazaki Y, Nagai R, Komuro I. Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J Biol Chem 2000;275:15239-45
Zhu W, Zou Y, Aikawa R, Harada K, Kudoh S, Uozumi H, Hayashi D, Gu Y, Yamazaki T, Nagai R, Yazaki Y, Komuro I. MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes. Circulation 1999;100(20):2100-7
Zou Y#, Zhu W#, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A, Komuro I. Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation 2003;108:3024-30
Monzen K#, Zhu W#, Kasai H, Hiroi Y, Hosoda T, Akazawa H, Zou Y, Hayashi D, Yamazaki T, Nagai R, Komuro I. Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes. Biochemical and Biophysical Research Communications 2002;298:493-500
Toko H#, Zhu W#, Takimoto E, Shiojima I, Hiroi Y, Zou Y, Oka T, Akazawa H, Mizukami M, Sakamoto M, Terasaki F, Kitaura Y, Takano H, Nagai T, Nagai R, Komuro I. Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart. Journal of Biological Chemistry 2002;277:24735-43
Zou Y, Yao A, Zhu W, Kudoh S, Hiroi Y, Shimoyama M, Uozumi H, Kohmoto O, Takahashi T, Shibasaki F, Nagai R, Yazaki Y, Komuro I. Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation 2001;104:102-109
Nagai T, Tanaka-Ishikawa M, Aikawa R, Ishihara H, Zhu W, Yazaki Y, Nagai R, Komuro I. Cdc42 plays a critical role in assembly of sarcomere units in series of cardiac myocytes. Biochemical and Biophysical Research Communications 2003;305:806-10
Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nature Cell Biology 2004;6:499-506
Gu Y, Zou Y, Aikawa R, Hayashi D, Kudoh S, Yamauchi T, Uozumi H, Zhu W, Kadowaki T, Yazaki Y, Komuro I. Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes. Molecular and Cellular Biochemistry 2001;223:35-46
Zou Y, Hiroi Y, Uozumi H, Takimoto E, Toko H, Zhu W, Kudoh S, Mizukami M, Shimoyama M, Shibasaki F, Nagai R, Yazaki Y, Komuro I. Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation 2001;104:97-101
Aikawa R, Nawano M, Gu Y, Katagiri H, Asano T, Zhu W, Nagai R, Komuro I. Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation 2000;102:2873-2879
Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Zhu W, Kadowaki T, Yazaki Y. Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. Circulation Research 1999;84(4):458-466
Zou Y, Komuro I, Yamazaki T, Kudoh S, Aikawa R, Zhu W, Shiojima I, Hiroi Y, Tobe K, Kadowaki T, Yazaki Y. Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts. Circulation Research 1998;82:337-345
二、基金项目
1. 国家自然基金(81672849):Wnt受体LRP5/6阻止GPCR诱导的肿瘤转移的机制研究,2016/01-2019/12,72万元
2. 国家自然基金(81470395):IGFBP-4作为阻止心肌缺血损伤药物可能性的探索研究,2015/01-2018/12,73万元
3. 上海市科委科研项目(14JC1405100):IGFBP-4对急性心肌缺血的干预, 2014/09-2017/08,16万元
4. 国家重点基础研究发展计划(2013CB945303):心肌细胞分化增殖及潜能及更新的分子信号网络研究,2013/01-2017/08,76.7万元,子课题负责人
5. 国家自然基金创新群体项目(81221001):心律失常发生机制研究,2013/01-2015/12,100万元,已结题,参与
6. 国家自然基金(81172024):Wnt受体LRP5/6抑制肿瘤细胞迁移的研究,2012/01-2015/12,55万元,已结题,主持
7. 国家重点基础研究发展计划(2011CB964904):胰肾干/祖细胞临床前安全性、有效性研究,2011/01-2015/12,750万元,已结题,组长
8. 国家自然基金(81070108):IGFBP-4诱导心肌细胞分化再生途径的探索,2011/01-2015/12,34万,已结题,主持