梁兴群

发布时间：2016-06-22 11:56:09 点击次数：2213

梁兴群，北京协和医科大学基础医学博士，教授，博士生导师。1996.07-2001. 05在芬兰赫尔辛基大学生物技术研究所担任博士后研究员和研究科学家；2001.05-2002.10在哈佛大学哈佛医学研究所担任博士后研究员；2002.10-2011.01在加州大学圣地亚哥分校医学系历任博士后研究员、研究科学家、研究副教授，并通过美国医生资格考试；2011.01 回国特聘为同济大学医学院病理生理学系、心律失常教育部重点实验室及同济大学附属东方医院医学转化平台教授、博士生导师和PI。

主要研究方向为心血管和神经系统的发育、功能及病变。主要研究成果以第一作者、共同作者在Nature，Nature Neuroscience， Circulation，Circulation Research和JCI等杂志发表。2011年回国工作后，作为通讯、第一和共同作者发表SCI论文17余篇，其中包括领域顶级杂志Circulation Research，JCI，BMC等。获国家自然科学基金面上项目，国家创新研究群体科学奖，973项目，上海市创新项目和上海市浦江人才计划等多项资助。

一、代表性论文

‍‍   Xingqun Liang, Sylvia M. Evans, Yunfu Sun. Development of the cardiac pacemaker. Cellular Biology Life Science. DOI 10.1007/s00018-016-2400-1.

  Ye M, Zhang Q, Xu X, Zhang Q, Ge Y, Geng P, Yan J, Luo L, Sun Y, Liang X. Loss of JAM-C leads to impaired esophageal innervations and megaesophagus in mice. Diseases of the Esophagus (2016) 29, 864–871.

  Tommi Anttonen, Xingqun Liang, Ulla Pirvola. c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea1,2,3.  eNeuro. 2016 Mar-Apr, Published online.

  Liang X*, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM. Isl1 Is an Essential Regulator of Pacemaker Development and Function. J Clin Invest. 2015 Aug 3; 125(8):3256-68.

  Liang X, Evans SM, Sun Y. Insights into Cardiac Conduction System Formation Provided by HCN4 Expression. Trends in Cardiovascular Medicine. 2015，25(1)：1-9

  Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, Gu Y, Dalton ND, Peterson KL, Poggesi C, Sheikh F, Chen J, Bang ML. Nebulette knockout mice have normal cardiac function, but showZ-line widening and up-regulation of cardiac stress markers. Cardiovasc Res. 2015 Jul 15;107(2):216-25. doi: 10.1093/cvr/cvv156. Epub 2015 May 17  

  Liang X, Evans SM and Sun Y. Insights into cardiac conduction system formation provided by HCN4 expression. Trends Cardiovasc Med. 2015 Jan;25(1):1-9.

  Dai X, Jiang W, Zhang Q, Xu L, Geng P, Zhuang S, Petrich BG, Jiang C, Peng L, Bhattacharya S, Evans SM, Sun Y, Chen J, Liang X*. Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 2013 Oct 16; 11:107.

  Zhuang S, Zhang Q, Zhuang T, Evans SM, Liang X*, Sun Y. Expression of Isl1 during mouse development. Gene Expr Patterns. 2013 Jul 29;13(8):407-412.

   Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y*, Evans SM*. HCN4 Dynamically Marks the First Heart Field and Conduction System Precursors. Circ Res. 2013 Aug 2;113(4):399-407. Epub 2013 Jun 6.

   Liang X, Song MR, Xu Z, Lanuza GM, Liu Y, Zhuang T, Chen Y, Pfaff SL, Evans SM, Sun Y. Isl1 Is required for multiple aspects of motor neuron development. Mol. Cell. Neurosci. 2011 April 26;8-15.

   Ye M, Coldren C, Liang X, Mattina T, Goldmuntz E. Benson W, Ivy D, Perryman MB, Garrett-Sinha LA, Grossfeld P. Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects in mice. Human Molecular Genetics. 2010;19:648.

   Liang X, Sun YF and Chen J. Particularly Interesting Cysteine- and Histidine-Rich Protein in Cardiac Development and Remodeling.  J Investig Med. 2009 Dec 57(8):842-8.

   Liang XQ, Sun YF, Yi MQ, Paul H Evans SE and Ju Chen. Inactivation of PINCH1 and PINCH2 Disrupts Cardiomyocytes Focal Adhesion, Resulting in Cardiomyopthy and Heart Failure. Circulation. 2009 Aug 18; 120(7):568-76. Epub 2009 Aug 3.

   Sun YF, Dykes IM, Liang XQ, Eng SR, Evans SM, Turner EE. A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci. 2008 Nov; 11(11):1283-93. Epub 2008 Oct 12.

   Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. A myocardial lineage derives from Tbx18 epicardial cells. Nature, 2008 Jul 3; 454(7200):104-8.

  Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomer mediates hypertrophic biomechanical stress response in mice. J Clin Invest. 2008;118:3870

   Sun Y, Liang X*, Najafi N, Cass M, Lin L, Cai CL, Chen J, and Evans SM. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol. 2007; 304(1):286-96. (*equal contribution)

   Liang X, Sun Y, Schneider J, Ding JH, Cheng H, Ye M, Bhattacharya S, Rearden A, Evans S, Chen J. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res. 2007; 100(4): 527-535.

   Sun YF, Liang XQ*, and Evans SM. (2007). Islet1 Progenitors in Developing and Postnatal Heart. Cardiovascular Development (ADB series). (*equal contribution)

   Sheikh F, Chen TH, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton NE, Yajima T, Lu YC, Fusch E, Knowlton KU, Peterson KL, Perriard JC and Chen J. alpha-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction Resulting in Cardiomyopathy and Susceptibility to Wall Rupture. Circulation. 2006; 114: 1046-55.

   Liang X, Zhou Q, Li X, Sun Y, Lu M, Dalton N, Ross J Jr, and Chen J. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol. 2005; 25(8):3056-62

   Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, and Evans SM. Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart. Dev Cell. 2003; 5:877

  Liang X, Hava Avraham, Shuxian Jiang, Tae-Aug Kim, and Shalom Avraham . Genetic alterations of NRP/B gene associated with human brain tumors. Cancer Res 2004; 23: 5890-5900. ‍‍

二、学术专著

1. Yunfu Sun, Liang X, and Sylvia Evans. (2007). Islet1 Progenitors in Developing and Postnatal Heart Cardiovascular Development. Advance in Developmental Biology. 2008 (18): 154-65.

2. Shalom Avraham, Hava Avraham, Shuxian Jiang, Xia Bu, Liang X, Seyha Seng  and Tae-Aug Kim (2002). The superfamily of proteins containing Kelch and/or BTB domains: From cytoskeleton dynamics to transcriptional regulation. Recent Res. Devel. Bio. Chem. (Review, book). 1:231-254.

三、基金项目

1. 国家自然科学基金面上项目 ：接头蛋白PINCH介导的信号通路在血管形成和维护中的功能、2017.01-2020.12、课题负责人。

2. 国家创新研究群体科学奖 ：81521061 、心律失常发生机制研究、2016.01-2019.12. 共同承担人。

3. 国家自然科学基金面上项目： 81370196、转录因子Isl1 在心脏起搏细胞的发育和功能中的调控机制、2014.01-2017.12 、课题负责人。

4. 学术领军人物和创新团队建设（千人建设计划）项目：islet1在心脏流出道发育中的作用、2014.01-2014.12、承担人。（结题）。

5. 973计划 ：2013CB531100 、心律失常的发病机制和干预机理、2013.01-2017-08、骨干。

6. 国家自然科学基金面上项目：81270409、整合素信号通路在血管形成中的作用、2013.01-2013.12 、课题负责人。（结题）

7. 预研类项目（1500219055）、课题负责人。（结题）

8. 国家创新研究群体科学奖 ：81221001 、心律失常发生机制研究、2012.01-2018.12. 共同承担人。（结题）

9. 国家自然科学基金面上项目 ：31171393、 ILK在心脏神经嵴细胞和流出道的形成中的作用及其分子机制、2012.01-2015.12 、课题负责人。（结题）

10. 上海市浦江人才计划： 12PJ1407400 、Isl1在心脏流出道形成中的作用及机制、2012.10-2014.09、课题负责人（结题）

11. 学术领军人物和创新团队建设（千人建设计划）项目：PINCH-ILK介导的细胞及细胞与细胞间质的相互作用、2011.01-2013.12、承担人。（结题）。

12. 上海市科委创新项目：12ZZ030 、PINCH介导的内皮细胞相互作用在血管形成中的作用及其分子机制 、2011.01-2014.12、 课题负责人（结题）

四、 荣誉和奖项

1. 中国医学科学院协和医科大学优秀博士生。

2. 1998–2001年国际耳鼻喉协会成员。

3. 加州大学杰出心血管研究舒尔曼奖。

4. 同济大学附属东方医院科研贡献奖。

5. 国家创新研究群体科学-团队奖。

6.  2012年上海市浦江人才计划。